I was wondering how many times your molds can be used? if i were to get a basic insert tooling mold would you be able to give me an estimate of how many times it could be used?

There is a range of machines used for injection molding. The cheapest option is a small desktop injection molding machine perfect for in-house projects. A small desktop injection molding machine is the most cost-effective choice for producing low volumes of parts.

Participant recruitment was from March 16, 2021, to July 18, 2022. The last visit was September 21, 2022. At the 6 sites, 3993 patients were admitted for management of OUD. Of those, 2443 did not attempt XR-naltrexone initiation for reasons including 848 preferred buprenorphine, 1085 preferred methadone treatment, and 280 preferred withdrawal management followed by no MOUD (eTable 4 in Supplement 2). A total of 415 participants (10.4%) were attempting to initiate XR-naltrexone and agreed to participate in the trial, with 225 enrolled in sites assigned to the RP and 190 in sites assigned to the SP (Figure 2); 37.3% of participants did not initiate XR-naltrexone. All participants were included in the primary outcome assessment of induction during the inpatient phase; 56% of the participants completed the final outpatient week 8 study assessment.

The primary outcome was dichotomous receipt of the first injection of XR-naltrexone during inpatient status. Secondary outcomes included opioid withdrawal severity, opioid craving, safety events, receipt of second and third XR-naltrexone injections, and opioid use as measured by self-reported days of opioid use and urine drug screen samples. All analyses were performed using SAS, version 9.4 (SAS Institute Inc), and were intention-to-treat, and prespecified in the trial protocol (Supplement 1) and in the trial statistical analysis plan (Supplement 3), apart from the Fisher exact tests for baseline differences, the Fisher exact tests on SAEs and overdose, and the χ2 test for follow-up injections, which were added post hoc.

Thank you for the request for quote, I appreciate the opportunity. I don’t know what that would take. The highest specific gravity for readily available material is around 1.4. I would recommend researching how that compares to what is currently used. I know that some law enforcement agencies are using rubber bullets now but I don’t know if any sort of ejection assistance is used. Please contact us via [email protected] if you’d like to discuss further.

Much needed information about the cost of plastic injection molds as knowing the price details are greatly helpful for the business.

Participants were recruited sequentially from patients with OUD seeking inpatient treatment at study sites. Clinical staff met with patients and reviewed MOUD options using a shared decision-making tool (eAppendix 2 in Supplement 2). All participating sites were well versed in the use of agonist-based treatment and encouraged all forms of MOUD. Study participation was only offered to individuals who expressed interest in XR-naltrexone treatment. Participants completed study consent up to 4 days from admission. Eligibility criteria were broad, allowing individuals with stable comorbid psychiatric, medical, and other substance use disorders to enroll.

The cost of the material you use for your project is usually decided by the design, material chosen, and the amount you need to complete the project. Here is a quick chart explaining more about each thermoplastic material, their features, common applications and price per pound.

Author Contributions: Ms Tafessu and Dr Hefner had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Hunter, That product would be too large for us, and would likely need to be extruded. Try searching http://www.thomasnet.com for a large capacity plastic extruder.

I’m doing a project and I was wondering how much would the injection mold cost for a width:10 inch length:15 inch height 3 inches the top lid would be the same dimensions.

The opioid epidemic continues to contribute to substantial morbidity and mortality,1 with more than 80 000 opioid overdose deaths in the US in 2022.1,2 Efficacious, Food and Drug Administration–approved medications for opioid use disorder (MOUD) that promote abstinence and protect against overdose include the full opioid agonist methadone, the partial agonist buprenorphine, and the antagonist naltrexone in an injected extended-release (XR) formulation (XR-naltrexone).3-5 Extended-release naltrexone may be particularly relevant for marginalized populations that may have less-favorable attitudes toward agonist-based treatments.6

Open Access: This is an open access article distributed under the terms of the CC-BY License. © 2024 Shulman M et al. JAMA Network Open.

SWIFT was conceptualized as a hybrid effectiveness-implementation trial in which trial procedures were implemented by the regular clinical staff members of the participating community-based inpatient treatment programs. However, site-based research teams developed working relationships with the clinical staff and contributed in varying degrees to patient care, limiting generalizability to non–research-involved programs. In addition, although all 6 sites made arrangements with local compounding pharmacies to purchase low-dose naltrexone at low cost, low-dose naltrexone is not on the formulary at most hospitals and therefore represents a barrier for widespread implementation. In addition, clinical teams were intensively coached by expert lead team clinicians, which may not be feasible on a large scale. More research is needed on sustainability, feasibility, and health economic aspects of this intervention. Substantially fewer days used with the RP is cost saving, but the resources needed for more intensive monitoring may outweigh these savings.

Race and ethnicity data were collected from patient self-report from the NIDA demographic questionnaire to provide information about the participants included in a study and to inform potential generalizability of the results. During the inpatient phase, assessments included daily monitoring of opioid withdrawal and cravings, medications administered, and weekly monitoring of depression and anxiety symptoms. Outpatient phase assessments occurred weekly (weeks 1-4) or every other week (weeks 4-8) and included monitoring of self-reported MOUD use, substance use, opioid cravings and withdrawal, and urine point of care urine drug screen samples (eTable 3 in Supplement 2). In addition to serious adverse events (SAEs), targeted safety events (TSEs) potentially related to detoxification were defined a priori based on previous studies5,13,16,17 and systematically collected. These included falls, acute medical complications, and acute changes in mental status or psychiatric symptoms.

What I have is four different geometrical round shapes of varying face counts with some small extruded borders between the faces. They’d be hollow so they’d be cut in a symmetrical manner so that two printed halves can be glued together to form a whole hollow sphere. All spheres are around 7,5 cm in diameter, about 3 inches, and half that in height due to them being halves. Additionally they’d have holes in specific places on the spherical surface but that could be drilled aftetwards, so just some sort of mark where the holes are supposed to be would be sufficient.

Objective  To compare the effectiveness of the standard procedure (SP) with the rapid procedure (RP) for XR-naltrexone initiation.

For the 206 participants who did not receive a first dose of XR-naltrexone, the most common reasons were chose to leave the inpatient unit early (RP: 52 [61.9%]; SP: 86 [70.5%]), decided to begin buprenorphine or methadone (RP: 18 [21.4%]; SP: 25 [20.5%]), and withdrawal symptoms too uncomfortable (RP: 12 [14.3%]; SP: 6 [4.9%).

“On the other hand, if you are going to need 100,000 xbox controllers every month, we would build a 12 cavity hardened “family” mold which made four Fronts, four Backs, and four Button Trees every cycle, and you’d better have $60-$80,000 or more to invest.” is the 6o-8o,ooo dollars a yearly investment or a monthly investment?

Thank you for the inquiry. If you submit CAD drawings we will provide a quote for the cost of the injection mold and production. Once the mold is built you own it and will only pay for production parts out of it. If the mold remains in our possession it comes with a lifetime guarantee. Hopefully this answers your questions.

The SP consisted of a 3- to 5-day buprenorphine taper followed by a 7- to 10-day opioid-free period before receipt of XR-naltrexone injection (eTable 1 in Supplement 2). Adjunctive medication regimens varied across sites (eTable 2 in Supplement 2).

Design, Setting, and Participants  The Surmounting Withdrawal to Initiate Fast Treatment with Naltrexone study was an optimized stepped-wedge cluster randomized trial conducted at 6 community-based inpatient addiction treatment units. Units using the SP were randomly assigned at 14-week intervals to implement the RP. Participants admitted with OUD received the procedure the unit was delivering at the time of their admission. Participant recruitment took place between March 16, 2021, and July 18, 2022. The last visit was September 21, 2022.

Procedures have been developed to shorten XR-naltrexone initiation by limiting the use of opioid agonists and using nonopioid medications proactively to manage withdrawal symptoms, together with gradually titrating small doses of oral naltrexone.9-12 In an outpatient single-site trial, this rapid initiation method was superior to the standard approach on the proportion of patients successfully initiating XR-naltrexone.13

Thanks for helping me learn more about plastic injection molds. I didn’t know that molds should be made from harden steel if a product needs a fiberglass filled material. I’m interested to learn how these molds could be made, especially of the steel mold needs to be really precise.

I’m glad you mentioned having a target price ready before designing a mold. I have a few things I want to start molding, but I hadn’t thought about a price yet. I can see how that would make a big difference in how they would plan how many parts to make.

Hello, I have designed a product that I believe the best way to manufacture will be through injection molding. I cannot share too much, but for the sake of this comment lets imagine that it is a hollow box with 1/4″ walls, 1 face missing, and that it is 1′ 8″ W x 1′ 11″ L x 1′ 3″ H. Now I understand that pricing is complex so I won’t ask you for a quote without sending the file, and I will assume that the mold will cost no less than $50,000 which is fine. My questions are below: – Considering the dimensions of the extents, is it possible to create a family mold with multiple units? What would be the maximum units per mold? And around how many could be banged out per day (again assume its a 1/4″ wall box as stated above for now)? – How long does the process of making the mold take (assuming the design and specs are ready)? – Do I have to pay the full amount immediately, or can it be paid in installments? – If I were to send over a .dwg file for a quote, are you legally bound by confidentiality? Thank you in advance!

Small sidenote, plan on leaving at least 0.250in of metal around all water lines. If not maintained properly they’ll eventually corrode thin walls. This consideration has occasionally led us to quoting larger mold bases.

We do mold with thermoplastic elastomers, which are still considered a plastic. It is more expensive than a lot of other types, and could add $.50 for a 100 gram part when compared to ABS.

Critical review of the manuscript for important intellectual content: Shulman, Greiner, Opara, Potter, Hefner, Jelstrom, Rosenthal, Wenzel, Fishman, Rotrosen, Ghitza, Nunes, Bisaga.

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Thanks for this post, somewhat it helped me understand more about plastic injection mold and an estimation on how much it costs.

Hi I’m trying to get a project started and luckily I found the guides and explanations here, good stuff. With the guide my estimate is somewhere between 15 000 to 30 000.

Thank you for the request for quote, we appreciate the opportunity. Unfortunately this product is too large for us. The largest footprint we can mold is approximately 100 square inches.

Findings  In a 6-site stepped wedge cluster randomized clinical trial that included 415 individuals with OUD, more patients successfully initiated XR-naltrexone using the rapid procedure (62.7%) compared with a standard (12-14 days) procedure (35.8%). The rapid procedure was shown to be both noninferior and superior, but had a higher number of safety events and serious adverse events and required more staff attention.

how much would a console mold cost and how many would i need? Same with controllers… do i need enough to make 100,000 a month?

If you’re thinking of outsourcing your mold-making overseas, consider all of the factors in bringing the mold to optimum production standards outlined in this American Mold Builders Association article. You might be surprised to learn the true cost of off-shoring!

The mean (SD) daily maximum COWS scores over the first 15 days of the trial are plotted in Figure 3. The proportion of days with a moderate or greater maximum COWS score (≥12) did not differ significantly between the SP and RP groups after controlling for site and day of admission (OR, 1.25; 95% CI, 0.62-2.50; P = .54). Day from admission was associated with a lower frequency of elevated COWS scores (OR, 0.74; 95% CI, 0.69-0.79; P < .001). The mean maximum Subjective Opiate Withdrawal Scale score also did not differ significantly after controlling for site and day of admission (mean difference, 1.79; 95% CI, −2.67 to 6.25; P = .43).

We do not have minimum order quantities, but there are set up fees amortized into each order so the cost effectiveness of low quantity orders is a decision left to our customers.

Thanks a lot for sharing this awesome info. Your article is excellent and informative. I love to read your articles.i personally like all the points you explain and follow it. Everyone should read this awesome post, I will share with my friends. Keep it up with such great content

Although not the primary focus of the study, the results highlight the problem of adherence in community-based outpatient follow-up (less than half of patients who initiated treatment received 2 subsequent monthly injections). This is consistent with observational studies reporting that XR-naltrexone has low rates of retention and poorer outcomes compared with buprenorphine or methadone,22,23 although controlled studies have not shown a substantial difference in retention.21,24 In addition, only 56% of participants completed the final study assessment and the trial was not powered to detect long-term differences in treatment outcomes (ie, relapse, overdose, and improvement in quality of life). More research is needed on how to prevent dropout from XR-naltrexone after it has been initiated, with more aggressive research follow-up to improve trial retention.

Main Outcomes and Measures  Receipt of XR-naltrexone injection prior to inpatient discharge (primary outcome). Secondary outcomes included opioid withdrawal scores and targeted safety events and serious adverse events. All analyses were intention-to-treat.

I always enjoy reading quality articles by an individual who is obviously knowledgeable on their chosen subject. I’ll be watching this post with much interest. Keep up the great work…

A substantial barrier to use of XR-naltrexone is the need to withdraw patients from opioid treatment to avoid precipitated withdrawal.7 The XR-naltrexone (Vivitrol; Alkermes Inc) prescribing information recommends a 7- to 10-day opioid-free period before administering XR-naltrexone.8 Assuming a typical 3- to 5-day buprenorphine taper for withdrawal from opioid treatment, this commonly used protocol adds up to 10 to 15 days before administering XR-naltrexone. During this extended period, patients are vulnerable to residual opioid withdrawal, cravings, and dropping out of treatment with the subsequent risk of overdose and death.

It is noteworthy that only 10.4% of all patients entering treatment chose to attempt XR-naltrexone initiation and even in the RP 37.3% of participants did not initiate XR-naltrexone. In future studies, the implementation strategies used in the present trial could be broadened to encompass initiation of buprenorphine and methadone, addressing the larger goal of maximizing the proportion of patients with OUD admitted to inpatient or residential treatment who emerge stabilized on MOUD.

Eloi, Thank you for the inquiry. Bottles are blow molded, not injection molded so we couldn’t answer that question. Here is a link to out knowledge base for more information: https://rexplastics.com/knowledge-base/product-development

I really like reading good articles by someone who knows a lot about what they’re writing. I’m excited to see more from you. Keep it up!

I’m considering syringe barrels to be injection molded. About 3 mL and 6 mL (two different sizes) with qty of 20,000 per month for now. Actually syringe barrels without the thread, but with luer male at the end. Just empty straight (slightly tapered). Material PP.

Chris, Thank you for the inquiry, I appreciate the opportunity. Without seeing the geometry it’s difficult to estimate cost. Our pricing guide can give an indication of cost, although it does not giving multi-cavity pricing.

Without seeing the specific design it’s difficult to give an estimate. Sometimes even small design features can add thousands to the cost of the mold. If you have a drawing we could provide a free quote.

hi I’m doing a school project and I need to know how much it will cost to make a simple 3,109 volumed container 12×14 container for the base and 12×14 for 2 sides and 14×20 for the other so 12=l 14=w 20=h

Thank you for the request for quote, we appreciate the opportunity. The best opportunity we have to help make your project a success is if we have as much information as possible. If you could fill out the request for quote form on our website it will be a big step in that direction. It includes questions about material, annual estimated production quantities, etc. as well as the option to upload drawings or photos.

Hi, Do you also provide molding with rubber or any other elastic material? Is it (NRE and price per part) usually more or less expensive than plastic ? tx, offer

Hi, Thanks for your valuable post… I really appreciate your great work. This post helped me understand more about plastic injection mold and estimation on how much it costs. An injection mold is easily the most expensive part of the project, and can dramatically increase costs for small part runs. The main factors that influence the cost of an injection mold are the size and intricacy of the part, the material used, and the number of parts being produced.

Thank you for the inquiry Ali. All of our molds have a lifetime guarantee so even if your mold wears, you won’t see a repair bill from us. Generally speaking a hardened steel mold or insert should last 100,000 cycles or more.

Meaning  The findings of this trial suggest that a rapid approach to withdrawal management should be considered for patients with OUD attempting to start treatment with XR-naltrexone, but more intensive staffing needs may be a barrier to implementation.

Kelsey, Thanks you for the inquiry. That’s difficult to say without seeing the part. Small details in the design can make big differences in cost to manufacture. If it is a simple design with no undercuts and the surface doesn’t require polishing, you could perhaps get a mold built for $5-$8,000. Here is a link to a pricing guide for further reference. https://rexplastics.com/injection-mold-price-guide

Jake, That is impossible to say without looking at the design, but as a general rule of thumb if you need 1,000 or more per year injection molding is worth looking at.

If your project requires large industrial molding machines that are operated by a service provider and large manufacturers, you’re looking at spending anywhere from $50,000 to $100,000+. Unlike the small desktop injection molding machine, these larger machines require professionals who can operate, maintain, and monitor the machine.

Rienk, Thank you for the inquiry. That’s difficult to estimate without more information, but generally speaking snap fit connections will add $500-$1,000 to the cost of a mold.

Simon, Thank you for your inquiry. It’s difficult to say, but you might be about right. Features that will effect tooling cost are the finish you would like on the parts (polished is more expensive than textured), and where the drilling marks are located. If there are undercuts created by them in relation to the direction the part will need to be ejected out of the mold, moving cores would need to be designed into the molds, which will significantly increase the cost. If these concerns could be worked out, we could probably build two molds to shoot these sets for $30-$60,000. If you would like tighter figures, we would need to see drawings or prototypes. Thanks again for the inquiry.

What would be the most logical approach if I wanted to create all four? All on one mold? Each geometrical type with their own mold? Then capacity wise, 10 000 a year? 100 000 a year?

Administrative, technical, or material support: Shulman, Opara, Potter, Hefner, Jelstrom, Rosenthal, Fishman, Rotrosen, Nunes, Bisaga.

Yes that is correct. After we build the mold (that you own), we store it here and run parts from it when you send us a PO.

The primary outcome analysis was prespecified to test noninferiority, because the rapid approach has a clear pragmatic advantage for patients and was therefore considered preferable even if the 2 approaches were similar in effectiveness. The statistical analysis plan prespecified that, if noninferiority is established (lower bound of the 95% CI of the odds ratio [OR], >0.67), we would establish superiority if the 95% CI is above 1.18,19 The analysis used a generalized linear mixed-effects model,14 with a logistic link and assuming observations are equally correlated within cluster (site) by treatment group, regardless of time period. The log odds of a participant receiving the first XR-naltrexone injection was modeled as a function of the procedure received (RP vs SP), time (study month or step) to control for secular trends, and a random effect for site to control for nesting of participants within the site. Observations were assumed to be equally correlated within the site (cluster), regardless of time period. Supplemental analyses related to the primary outcome tested for a fixed effect of treatment by time interaction, which, if significant, would indicate differential impact of treatment across time. Sensitivity analyses of the primary outcome were performed to account for different correlation structures.14,20 Subgroup analyses were performed to examine intervention effect within subgroups defined by age, sex, and race and ethnicity.

The recruited participants had a mean (SD) age of 33.6 (8.48) years and consisted of 210 (50.6%) individuals identifying as female sex; male sex, 205 (49.4%); male gender, 187 (45.1%); female gender, 182 (43.9%); and transgender/nonbinary, 2 (0.5%); 5 (1.2%) identified as American Indian or Alaska Native; Asian, 6 (1.4%); Black, 54 (13.0%); Hispanic, 91 (21.9%); White, 290 (69.9%); and multiracial, 22 (5.3%). Demographic and clinical characteristics and comparisons using Fisher exact tests on the differences between arms of the study population are presented in Table 1.

The SWIFT trial was a 70-week, stepped-wedge, cluster-randomized design trial14 conducted at 6 geographically diverse, community inpatient addiction treatment programs in the US. Inpatient sites (American Society of Addiction Medicine level 3.7 or higher) were selected from across the National Institute of Drug Abuse (NIDA) clinical trials network and had a sufficient volume of inpatient admissions with OUD. At the start of the trial and at 14-week intervals, 1 site at a time was randomly assigned to switch from their standard procedure (SP), which followed the Vivitrol prescribing information8 to initiate XR-naltrexone, to the RP; the sixth site continued their SP throughout the trial (Figure 1). Randomization was conducted centrally through the Emmes NIDA Data and Statistics Center. SWIFT was approved at all sites by Biomedical Research Alliance of New York, and informed consent was obtained from all participants; financial compensation was provided. Methodologic details of the study were published previously15 and are available in the Trial Protocol in Supplement 1. The reported findings follow the Consolidated Standards of Reporting Trials (CONSORT) reporting guideline for randomized studies.

Injection molding cost can range anywhere from $100 to $100,000+ depending on the scope and intricacy of the project. A small and simple single-cavity plastic injection mold usually costs between $1,000 and $5,000. Very large or complex molds may cost as much as $80,000 or more. On average, a typical mold that produces a relatively simple part small enough to hold in your hand costs around $12,000.

Shulman M, Greiner MG, Tafessu HM, et al. Rapid Initiation of Injection Naltrexone for Opioid Use Disorder: A Stepped-Wedge Cluster Randomized Clinical Trial. JAMA Netw Open. 2024;7(5):e249744. doi:10.1001/jamanetworkopen.2024.9744

Hi, I am interested in creating 6 different plastic figurines, each one in a 6 and a 12 in size. would I need to purchase a separate mold for each figurine and size? These would be low production, at least in the beginning, for retail and online sales. Are there options to have them manufactured in color? For example, skin tone, clothing and hair color?

However, needing 100,000 Xbox controllers every month is a different story. For this requirement, we would recommend building a 12-cavity hardened “family” mold, which would make four Fronts, four Backs, and four Button Trees every cycle. Of course, this type of mold comes with a cost. You’d better have $60-$80,000 or more to invest!

I understand that the small extrustion between the faces of the spheres could be an issue when removing the part from the mold, so they would not be a necessity. The geometrical shapes are just a collection of planar faces which create a sphere.

As a full-service plastic injection molding company that manufactures molds from conception to completion, pricing for each job we fulfill can vary dramatically.

Hello, Just so I’m clear, you would charge for the creation of the mold, and then create the parts as needed/requested? You would see me back a finished product correct – as in you supply the materials, ship, etc? Thank you.

Sites were trained on the RP through an implementation facilitation process beginning 8 weeks before the scheduled switch to RP implementation. Expert clinicians on the lead research team served as external facilitators and a local implementation team was formed at each site, consisting of administrators and clinicians who served as champions and local trainers. This team met with the lead research team weekly for 1-hour sessions to work out logistics and for didactic trainings provided by lead team clinicians. After RP implementation, the teams met as needed (at a minimum, every week for the first 4 weeks of implementation). Once sites were comfortable in implementing the RP, site coaching shifted to collaborative meetings that included all sites assigned to the RP. Sites assigned to the SP met as a group with the lead research team every 1 to 3 weeks to review clinical issues.

I’m working on a school invention project and I need to know how much a mold for a half-pipe like design would cost. The thickness of the mold needs to be 1.5 inches, it is 1.5 feet high (bottom to top), 5 feet wide (left to right) and is 20 feet long (front to back). If you can estimate the price to the nearest thousand, that would be great. Thank you.

Hello, When submitting CAD specs to you or any injection mold company, do you recommend a Non-Disclosure Agreement be signed to protect a project?

I needed 1000 unit of enclosure (approx size 100 x 100 x 23 mm, fillet corner radius 20), Finishing should be fine as much as possible. I have seen the mould manufacturing costs a lot, is there any other way to manufacture enclosures at lower cost.

Safety events occurred at low frequencies overall (Table 2) but were more frequent in the RP than the SP group, particularly for TSEs; during the initiation/inpatient period, this was related to more falls and medical complications, while during the 2-month outpatient follow-up period, this was related to more falls, medical complications, and psychiatric or mental status problems. The frequency of TSEs was not significantly different between groups during the initiation period (RP: 12 [5.3%]; SP: 4 [2.1%]; P = .12; Fisher exact test), but was significantly greater in the RP group during the outpatient period (RP: 15 [6.7%]; SP: 3 [1.6%]; P = .01; Fisher exact test). During the 8-week follow-up period, 3 participants (1.3%) in the RP group and 6 (3.2%) in the SP group reported nonfatal overdose.

Corresponding Author: Matisyahu Shulman, MD, New York State Psychiatric Institute, Columbia University Irving Medical Center, 1051 Riverside Dr, New York, NY 10032 (matisyahu.shulman@nyspi.columbia.edu).

Additional Contributions: We are grateful for the contributions of the participants, the sites, and the staff involved in this study. We acknowledge the technical review and analytic contributions of Emmes colleague, biostatistician Travis Lilley, who died before this publication.

Material selection is another consideration in determining what plastic injection molds cost. Any plastic product made from fiberglass-filled material, for example, will wear down most common molds. Only a mold made from hardened tool steel can withstand injection molding with fiberglass-filled material.

Disclaimer: The views and opinions expressed in this article are those of the authors only and do not necessarily represent the views, official policy, or position of the US Department of Health and Human Services or any of its affiliated institutions or agencies. Dr Ghitza was substantially involved in UG1 DA013035-19, consistent with his role as NIDA Scientific Officer.

That’s why we’ve compiled the following price guide to help you budget for your mold. The injection molding cost examples are categorized by type (Rapid Prototyping, Insert Tooling, High-Production Tooling), and degree of difficulty (Basic, Intermediate, Advanced).

The last thing to consider when pricing out your injection molding cost is the cost of service or professional labor you will need. Professionals can help you set up the necessary equipment to create molds and your products. During the process, they’ll be able to replace defective parts and monitor the progress of the overall process.

First you locate and orient the part in the tool, which mainly depends on where/how you intend to gate it. For all gate types except center, you should have at least 0.75-1.00in of space between the sprue and the edge of the cavity. Once you have a cavity layout (assume centered sprue), determine its bounding box. Any space off-center will need to be mirrored on the other side of the sprue and included in this bounding box. In a sense, you’ll always be sizing a mold for two cavities unless you’re center-gating. For smaller molds under 12in per side (in the parting plane), you can get away with leaving 2in of space all around this bounding box. This space is occupied by the ejector housing, return pins, and leader pins among other things, all of which would interfere with the part cavities and/or their ejection. You may need extra space for cooling lines as well. For larger molds up to 24in per side, you’ll want at least a 2.5in perimeter.

The $60-$80,000 is a non-recurring expense to build the mold. Once the mold was built you would just pay for production parts as need. Probably around $1 per set at that point.

Your estimate cost for a steel p20, one cavity, cold runner, polypropylene 30%Gf matrix, with sizes of: 660mm x 220mm x 200mm. Thanks.

Do you need design-for-manufacturing (DFM) assistance? Or, are you ready for production? We have a full suite of services to offer and a lifetime mold guarantee.

Results  A total of 415 participants with OUD were enrolled (mean [SD] age, 33.6 [8.48] years; 205 [49.4%] identified sex as male); 54 [13.0%] individuals identified as Black, 91 [21.9%] as Hispanic, 290 [69.9%] as White, and 22 [5.3%] as multiracial. Rates of successful initiation of XR-naltrexone among the RP group (141 of 225 [62.7%]) were noninferior to those of the SP group (68 of 190 [35.8%]) (odds ratio [OR], 3.60; 95% CI, 2.12-6.10). Withdrawal did not differ significantly between conditions (proportion of days with a moderate or greater maximum Clinical Opiate Withdrawal Scale score (>12) for RP vs SP: OR, 1.25; 95% CI, 0.62-2.50). Targeted safety events (RP: 12 [5.3%]; SP: 4 [2.1%]) and serious adverse events (RP: 15 [6.7%]; SP: 3 [1.6%]) were infrequent but occurred more often with RP than SP.

Thank you for the inquiry. That does sound like something we can help you with but would need more information. Can you provide drawings or a link to a similar product? If so please send them to [email protected]

But at least to some degree, asking what plastic injection molding costs is a lot like asking, “How much is a car?” Will your mold be a Pinto or a Porsche? And don’t forget that the price of a mold is just the beginning. To determine overall plastic injection molding costs for any project, you have to consider raw material, operation, and repair costs later down the road, too.

The start-up costs for a large run can be expensive, but the price for the project becomes better and better as you continue to produce. If you’re looking at price per unit, plastic injection molding is one of the cheapest, most cost-efficient forms of manufacturing. With injection molding, the more units you create with your mold, the cheaper the price per unit becomes.

Hi, thanks for your contribution on Injection molding . I have basic knowlegde on mold design and would like to know how can I estimate overall mold dimensions based on part dimensions, considering one cavity mold and and no side actions. Also would like to know how can I estimate the approximate size of a slider for a side simple hole. Thanks for you support. Much appreciate. Regards

If you would like to send any drawings you have to our contact email directly we can provide an estimate. [email protected]

The RP uses aggressive oral hydration and additional nonopioid medications via standing doses. This appears to control withdrawal symptoms, as opioid withdrawal symptoms were low on average and did not differ significantly between the RP and SP (Figure 3). Safety events related to withdrawal procedures were infrequent overall but were more common with the RP (5.3% vs 2.1%) (Table 2). The significantly greater incidence of TSEs, in particular psychiatric events, after induction, may relate to the RP placing more stress on the cardiovascular and nervous systems, although greater baseline psychiatric severity may have played a role. The RP therefore requires more intense monitoring and clinical expertise, and this may not be feasible in some settings.

Acquisition, analysis, or interpretation of data: Shulman, Greiner, Tafessu, Ohrtman, Potter, Hefner, Rosenthal, Wenzel, Fishman, Rotrosen, Ghitza, Nunes, Bisaga.

Thank you for the request for quote, I appreciate the opportunity. The best opportunity we have to help make your project a success is if we have as much information as possible. If you could fill out our request for quote form our website it will be a big step in that direction. It includes questions about material, annual estimated production quantities, etc. as well as the option to upload drawings.

Question  Can the opioid antagonist injectable extended-release (XR)-naltrexone be started in patients with active opioid use disorder (OUD) with a rapid (5-7 days) procedure?

If you wouldn’t mind, how much would you ball park the cost to produce the mold, and the parts, of a standard size plastic shopping cart? Needing 100,000-500,000 units per year. I appreciate your time.

Funding/Support: The study was supported by the NIH HEAL Initiative UG1 DA013035-19. The Emmes Clinical Coordinating Center was funded by contract 75N95020D00012 for August 2020 to August 2025 and contract HHSN271201500065C for August 2015 to August 2020. The Emmes Data and Statistics Center was funded by contracts 75N95019D00013 and 75N95022D00017. The NIH and NIDA), Emmes Company LLC, and Alkermes Inc donated Vivitrol for this study.

I have an Idea…know nothing about this process, but here it goes. I wan’t to make a tool that will need Insert Molding? I know it’s a pricey operation, but to make it a durable and lasting tool it will have to be. I’d also like to have 6 to 8 tools made per cycle of the mold. the product would only be approx 5 to 6 inches long and 3/4 inch wide and approx 1/4 inch deep (approx). any idea (general idea) what this process would cost? I know there are many more details for plastic and metal applications, but a round about idea for a the mold would be helpful. Thank you.

In the RP, 141 of 225 individuals (62.7%) received XR-naltrexone compared with 68 of 190 (35.8%) in the SP (OR, 3.60; 95% CI, 2.12-6.10). The noninferiority test determined that, since the lower bound of the OR exceeded 0.67, noninferiority was demonstrated. Secondarily, it was determined that, since the lower bound of the OR exceeded 1.0, it was consistent with superiority (P < .001). The fixed effect of step was not significant (F4,24 = 1.112; P = .37), indicating no significant impact of the step on the primary outcome. Subgroup analyses of sex, age, and race and ethnicity showed no statistically significant interaction terms, implying the effects of initiation procedure did not differ across subgroups. The mean (SD) times to injection from admission were 7.0 (1.42) days (range, 4-12 days) with the RP and 14.5 (3.57) days (range, 7-23 days) with the SP.

Thank you for the inquiry. That does sound like something we can help you with. If you could please fill out our request for quote page on this site we can provide a quote. You can upload drawings there as well.

Nicole, Thank you for the inquiry. A Jackson Pratt bulb is blow molded, not injection molded. Please see this article for more explanation. https://rexplastics.com/plastic-injection-molding/the-many-processes-of-plastic-part-manufacturing

We have not made any golf disc parts specifically but that is well within our capability. Please contact us for a free quote if you are interested.

This post helping me understand more about plastic injection mold and estimation on how much it costs. And I learned from your post what an injection mold is made of

Thank you for your inquiry. Here is a link to a pricing guide that will get you headed in the right direction. https://rexplastics.com/injection-mold-price-guide Rex Plastics, Inc

Johnny, Thank you for the inquiry. Non-disclosure agreements are common in manufacturing so any molder you choose should not resist signing one unless it’s determined to lack certain exclusions and the ability of the molder to disclose information to third parties with written permission. Molders will often need to involve third party companies in order to provide a quote.

The determining factors in the cost of your mold are a combination of the part size, complexity, material, and anticipated quantities. For instance, if you wanted 1,000 washers per year, we would recommend a single cavity mold, meaning it makes one washer per machine cycle. In that case, the mold would probably be $1,000-2,000.

For slides, start by sizing the slide face. This is the block which will have the undercut detail cut into it. The face doesn’t need to be much larger than the undercut itself, but it should be rectangular or circular just for ease of manufacturing and assembly. The surrounding part geometry could factor into this too, if the undercut is in a cramped spot or located near/on curved surfaces. Leave perhaps 0.375-0.500in of steel behind the undercut detail (same idea behind determining cavity plate thickness) and assume a 0.50-1.00in perimeter on either side of the face for other hardware like guide rails, and 1.0-2.0in above and below the face for wear plates, heel blocks and bolts. The slide may well take up more space than your cavities, and drive the mold size and plate thickness all by itself.

Hi am new here, after I submit the CAD file will I pay $60 we part or I don’t understand. after making mold what part will I pay for again?

Would it be possible for me to request solely 2 units for my design initiative? They are quite large with a 1-meter diameter and 1.5-meter length. How much would it cost for the production of this?

Hi, Thank you for all the valuable information laid out on your site. My company has created molds and manufactured exclusively overseas, but I have tried to bring my business back stateside many times and have always found it difficult, biggest issue being MOQs. When creating a new product as a small business it’s difficult to run thousands or tens of thousands of units on a first run for an unproven product. My question is, after the mold is produced what is the average MOQ? What is your typical floor? What are the determining factors for the MOQ?

It’s worth looking into the mold base CAD libraries out there, such as through PCS. They’ll generate full, downloadable 3D CAD of their offerings based on the specs you plug into their forms.

Improving the rate of XR-naltrexone initiation using the rapid procedure (RP) in community-based treatment settings could be an important step to ensure more patients with OUD have the option of initiating XR-naltrexone, if this is their preferred medication treatment. The NIDA Clinical Trials Network CTN-0097 Surmounting Withdrawal to Initiate Fast Treatment with Naltrexone (SWIFT) trial was conducted to test the effectiveness of the rapid XR-naltrexone initiation procedure compared with usual care at community-based inpatient addiction treatment units.

I’d be interested in finding out about plastic molded 9mm projectiles. There would have to be a denser plastic chosen, so there is enough recoil generated by the exiting projectile to cycle a semi-automatic pistol reliably.

Conclusions and Relevance  In this trial, the RP of XR-naltrexone initiation was noninferior to the standard approach and saved time, although it required more intensive medical management and safety monitoring. The results of this trial suggest that rapid initiation could make XR-naltrexone a more viable treatment for patients with OUD.

Thank you for the inquiry. Unfortunately this product is too large for us. The largest footprint we can mold is approximately 100 square inches.

The target sample size of 450 participants (15 participants per step ×6 sites ×5 steps) was chosen to provide robust power (88%) to detect noninferiority of RP to SP, assuming a true probability of successful XR-naltrexone initiation of 70% on RP vs 55% on SP and a noninferiority margin of 10% (eg, observed successful XR-naltrexone initiation of 45% on RP vs 55% on SP), corresponding to the lower bound of the 2-sided 95% CI for the OR for RP vs SP above 0.67. The intraclass correlation (ie, the correlation between 2 participants within the same site) was assumed to be 0.14, based on prior data.21 The primary outcome and the supportive analysis for the primary outcome used a 1-sided test with 2.5% type I error rate. A similar error rate was used for the test of superiority.

Hi, Would you be able to create a mold for a golf bag, and provide a quote? Approximately 35″ tall, with a diameter of 11.5″ x 10″. I’d also like to include dividers in the middle. Thank you.

Participants received the initiation procedure (ie, SP or RP) that their program was assigned to at the time of their admission. After the inpatient stay, participants were referred for outpatient addiction treatment according to each site’s SPs and were followed up for 8 outpatient weeks; the second and third XR-naltrexone injections were offered at weeks 4 and 8 after the first injection.

Unfortunately this product is too large for us. The largest footprint we can mold is approximately 100 square inches, and the tallest piece around 10″.

These examples are extreme, but they illustrate the range of costs to anticipate. Your particular part will most likely fall somewhere in between that. At Rex Plastics, our molds average around $12,000.

In order to understand what the injection molding cost of your project may be, you need to understand the process and factors that will affect the price of your project.

We could put multiple figurines in one mold but injection molding may not be the best process if you are anticipating low volumes. 1,000+ per year may start to make sense for injection molding, otherwise you may want to talk to a plastic prototyper or polymer casting company. We can mold them in any color, but the entire figurine would be the same color. If you have drawings you can attach them to our Quote Now link and we can provide a quote.

Withdrawal ratings during the initiation phase were analyzed using a mixed-effects model adjusting for initiation procedure, step, site, and inpatient day as fixed effects and participant as a random effect. The Subjective Opiate Withdrawal Scale score was modeled as a continuous measure, while the COWS score was modeled as a binary measure for the presence of at least 1 moderate to severe daily COWS score (maximum score ≥12). Proportions of SAEs, overdose, and TSEs by initiation procedure were compared using the Fisher exact test.

If you have a target price established for your parts, tell your mold builder. They can design the mold accordingly and plan for the right number of cavities to achieve that price. The more cavities (or parts made per cycle), the less expensive the parts will be, also allowing for higher output.

Interventions  Standard procedure, based on the XR-naltrexone package insert (approximately 5-day buprenorphine taper followed by a 7- to 10-day opioid-free period and RP, defined as 1 day of buprenorphine at minimum necessary dose, 1 opioid-free day, and ascending low doses of oral naltrexone and adjunctive medications (eg, clonidine, clonazepam, antiemetics) for opioid withdrawal.

Would like to mold adult male lacrosse stick heads, wondering how much each can cost, or how much a plastic injection machine would cost.

This cluster trial demonstrated that an RP for initiating XR-naltrexone consisting of minimal buprenorphine, use of higher doses of nonopioid medications for opioid withdrawal, and titration of low doses of oral naltrexone is feasible, relatively safe, and noninferior, compared with the SP recommended in the XR-naltrexone prescribing information. The RP requires close medical monitoring. Due to its shorter duration, the RP may be cost-effective and a better fit within constraints on the duration of inpatient stays imposed by third-party payers.

George, Thank you for the inquiry. This product is too large for us but I will try to answer your questions. -You can have a multiple cavity mold made for this part. If you built a four cavity mold you would need at least a 5,500 ton molding machine (and about $200,000 for a domestically made mold). -With that mold you would probably get four parts every 2 or 3 minutes. -A single cavity mold would still be over $50,000. -Normally toolmakers will ask for 50% down with the remainder due once samples out of the mold are approved. -Toolmakers and molder are not bound to confidentiality unless you have them sign a non-disclosure agreement. Hopefully this helps, good luck!

Conflict of Interest Disclosures: Dr Hefner reported having a contract with the National Institute on Drug Abuse (NIDA) Clinical Trials Network (CTN) during the conduct of the study. Dr Jelstrom reported contract work from the NIDA Clinical Coordinating Center during the conduct of the study. Dr Wenzel reported receiving grants from the National Institutes of Health (NIH) during the conduct of the study and grants from Alkermes Inc outside the submitted work. Dr Fishman reported receiving grants from the NIDA and study medication from Alkermes during the conduct of the study; consultant fees and study medication from Alkermes, consultant fees from Indivior for staff training, study medication from Braeburn, consultant fees from Nirsum Laboratories, and Drug Delivery LLC; and grants from Alkermes to the institution outside the submitted work. Dr Rotrosen reported receiving grants from the NIDA/NIH, study medication from Alkermes, which provided Vivitrol and, in some cases, funds for studies conducted at NYU and, in some cases, sponsored and/or funded by the NIDA, and nonfinancial support from Indivior, which provided buprenorphine and, in some cases, funds for studies conducted at NYU and sponsored and/or funded by the NIDA during the conduct of the study; grants from the NIDA/NIH, nonfinancial support from Alkermes, which provided Vivitrol and, in some cases, funds for studies conducted at NYU and sponsored and/or funded by NIDA, and nonfinancial support from Indivior, which provided buprenorphine and in, some cases, funds for studies conducted at NYU and sponsored and/or funded by NIDA outside the submitted work; and is currently involved in studies using injectable buprenorphine in some cases supplied by Indivior or Braeburn. Buprenorphine and injectable buprenorphine could be considered a Vivitrol competitor. In all cases, funds were provided only to either NYU or NIDA. Dr Nunes reported receiving nonfinancial support from Alkermes and has been an investigator on NIH-funded studies that receive in-kind medication from Alkermes outside the submitted work. Dr Bisaga reported receiving grants and medication samples from Alkermes during the conduct of the study; and medication samples from Sophrosyne and Go Medical outside the submitted work. No other disclosures were reported.

While you don’t need to know every detail about the types of molds available, it’s always a good idea to come prepared. Supplying the basics to your mold builder will help them build the best tool for your project. We recommend that you find a mold maker who also has production capabilities. The production company won’t want to build an inadequate mold because they know they must use it.

Materials used in injection molding are plastics, specifically thermoplastics. There are hundreds of thermoplastics, but the most common thermoplastics used in injection molding are:

I’m working on a school project, I was wondering how much it would cost to make a mold that contains 25 cavities, the part is kind of cylindrical and I was planning to have it made out of high density polyethylene. It has a hole straight through the part with an inside diameter of 0.515″ and an outside diameter of 0.670″ for 0.773″ of the height and an outside diameter of 1.340″ for the remaining 0.327″ of the height, the height is 1.100″ total. This is the link to the photo: https://drive.google.com/file/d/0BxyuyPDgKAbnMXdHbE1GeTA5bms/view?usp=sharing https://drive.google.com/file/d/0BxyuyPDgKAbnN0xMSjJkNzdIUE0/view?usp=sharing

Thank you for the inquiry. Mold balancing plays an important role in injection molding, because of that we would recommend a 24 cavity mold. The parts are divisible in pairs with that amount and will run much better. The ballpark estimate for a cold runner mold that size would be $15-$20,000, and the part price would be under $.09 each for 20,000 parts ordered.

This stepped-wedge, site-level randomized clinical trial conducted across 6 community inpatient addiction treatment programs showed that an RP for initiation of XR-naltrexone was noninferior to an SP and led to a substantially greater number of patients receiving a first injection (62.7% vs 35.8%). The trial also highlighted the difficulty in starting XR-naltrexone, with 37.3% of participants not initiating XR-naltrexone treatment even with the more effective RP. Nevertheless, our study supports previous findings7 that a small but sizable number of individuals prefer treatment with an opioid antagonist when offered all 3 medication options and demonstrates a faster, more successful pathway to XR-naltrexone initiation that should be considered.

Role of the Funder/Sponsor: The funding organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

The RP required approximately 5 to 7 days (eTable 1 in Supplement 2). This included a single day of buprenorphine administration at the minimal dose needed to control withdrawal symptoms. Beginning 2 days after buprenorphine initiation, participants received a 3- to 4-day titration of oral naltrexone, from 0.5 to 6 mg, in 2 divided doses. During this titration, the first daily oral naltrexone dose was given if the participants’ Clinical Opiate Withdrawal Scale (COWS) score was less than 6. The COWS has a score range of 0 to 48, with higher scores indicating more severe withdrawal. The second dose was given 3 to 4 hours later. This dose was skipped if there was a 3-point or more increase in the COWS score after the initial dose to avoid worsening withdrawal. On the third day of naltrexone titration, XR-naltrexone, 380 mg, was administered if the COWS score did not increase after a 6-mg oral naltrexone dose. The naltrexone for the trial was procured by each site from local compounding pharmacies to reflect clinical practice implementation. Nonopioid medications for withdrawal were administered throughout the RP as standing doses. These included clonidine, 0.1 to 0.2 mg, every 4 hours (withheld for low blood pressure or heart rate), clonazepam, 1 mg, every 6 hours (held for oversedation), daily antinausea medication (prochlorperazine, 10 mg, or ondansetron, 8 mg), a sedative agent at bedtime (eg, zolpidem, 5-10 mg; trazodone, 50-100 mg), and nicotine replacement therapy (patch and gum) if needed. Further medications were given as needed. Electrolyte-rich beverages were encouraged, with at least 1 to 2 cups given every 4 hours. Given the potential adverse effects with clonidine and clonazepam (eg, orthostatic hypotension, dizziness, and gait instability), sites were advised to provide education and closely monitor patients for fall risk. Individuals who left the unit before XR-naltrexone initiation were strongly encouraged to begin another form of MOUD by clinical staff. A detailed order set was provided to clinicians (eAppendix 1 in Supplement 2).

Thanks for the inquiry. This post helping me understand more about plastic injection mold and estimation on how much it costs. And I learned from your post what an injection mold is made of.

In the RP, 31.7% (69 of 225) individuals received the second injection and 21.3% (48 of 225) received the third injection. In the SP, 23.7% (45 of 190) received the second injection and 16.8% (32 of 190) received the third injection. Receipt of the second (P = .11) or third (P = .25) injection in those who were initiated on XR-naltrexone did not differ significantly between the groups.

Hi, what are the estimated costs of a mold for a part with snap fit connections compared to the same part but instead of snap fit connections holes for bolts?

Great insights on the importance of precision in manufacturing. As a Welding and cutting machine manufacturers , Weldarc India understands the need for accuracy in welding and cutting processes. Our machines are designed to meet the demands of modern manufacturing with enhanced efficiency and precision. It’s exciting to see advancements in the industry that push the boundaries of what’s possible. Looking forward to continued innovations in welding and cutting solutions that contribute to high-quality production outcomes.

Bottom line in regards to NDA is whether or not you trust the molder. If they are a legitimate company that has been around for a long time, they’re probably not stealing people’s ideas. If you are naturally a cautious person or something doesn’t seem right with the molder, you’ll feel better having one in place. Hope this helps, let us know if you have and NDA you’d like us to review or if you would like to look at the one we use.

Importance  Injectable extended-release (XR)-naltrexone is an effective treatment option for opioid use disorder (OUD), but the need to withdraw patients from opioid treatment prior to initiation is a barrier to implementation.

As for plate thickness, leave at least 0.5in of steel between the upper and lowermost cavity extremities and the backsides of the cavity plates/cores. Depending on part geometry, you might need up to one full inch above and below the cavities for water lines.

Riser height will depend on how far the ejection needs to push your part before it’s completely free of the cavity and any cores. Completely free in this case meaning pushed all the way out/off so that there’s no chance it’ll get hung up on anything.